Cholestasis of pregnancy

  • Kosjenka Dermit Department of Gynecology and Obstetrics, Clinical Hospital „Sveti Duh“, Zagreb
  • Maja Brkic Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
  • Tihana Galic Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
  • Marta Orlovic Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
  • Ana Marija Krznaric Lovosevic Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
  • Ivona Plesa Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
  • Vladimir Blagaic Clinical hospital Sv.Duh, Sv.Duh 64, HR-10000 Zagreb
Keywords: bile acids, cholestasis, pregnancy, pruritus

Abstract

Cholestasis of pregnancy is a dysfunction of the liver characterized by pruritus and increased concentration of bile acids in the plasma during the second and third trimester. The cause of cholestasis of pregnancy is unknown, but it is believed to be connected to genetic factors and high values of the pregnancy hormone, which causes a disorder in the transport of bile acids in liver ducts. The leading symptom is pruritus, which is often generalized, but dominant on the palms and soles of the feet, and worsens during the night. Cholestasis of pregnancy is dangerous because it increases the risk of spontaneous preterm birth, meconium stained amniotic fluid, fetal distress, and intrauterine fetal death.

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Published
2017-09-30
How to Cite
Dermit, K., Brkic, M., Galic, T., Orlovic, M., Krznaric Lovosevic, A. M., Plesa, I., & Blagaic, V. (2017, September 30). Cholestasis of pregnancy. BioMedicine and Surgery, 1(3), 121-124. https://doi.org/https://doi.org/10.5281/zenodo.1219189
Section
Review