Focal nodular hyperplasia: a case report and literature review

Authors

  • Mario Kopljar Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek
  • Goranka Škeva Clinic for Occupational Medicine, Zagreb County Health Center, Samobor, Croatia
  • Andrea Milostić-Srb Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek
  • Tihomil Žiger Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek
  • Zrinko Madžar University Hospital Center "Sisters of Charity"

DOI:

https://doi.org/10.5281/zenodo.5792071

Keywords:

focal nodular hyperplasia, oral contraceptives, occupational medicine, rehabilitation, surgery, liver

Abstract

Focal nodular hyperplasia (FNH) is a rare benign hepatic tumor that originates from epithelial tissue and composed mainly of hepatocytes and Kupffer cells. It is usually present as an asymptomatic abdominal mass and is typically an incidental diagnosis because majority of patients lack symptoms. Symptoms are more frequent in women using contraceptive steroids. It must be distinguished from other more common benign and malignant lesions because of different therapeutic approaches. It occurs in all age groups, but more than 50 % of the patients are women between 25 and 44 years.

The etiology of this condition remains obscure. Various causes have been proposed for FNH, including localized ischemic injury related to vascular anomaly, vascular injury such as thrombosis and induction of hepatocellular proliferation by oral contraceptive steroid ingestion (OC).  The standard treatment of FNH is to manage asymptomatic lesions conservatively and operative resection of symptomatic ones.

We present the clinical course as well as the clinicopathologic implication of a 20-year-old female adolescent with FNH who wasn’t OC users and review this rare hepatic lesion in the literature.

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Published

2017-12-19

How to Cite

Kopljar, M., Škeva, G., Milostić-Srb, A., Žiger, T., & Madžar, Z. (2017). Focal nodular hyperplasia: a case report and literature review. BioMedicine and Surgery, 1(4), 162–166. https://doi.org/10.5281/zenodo.5792071

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Review