Primary Non-Hodgkin's Lymphoma of the Bone: A case report


  • Marijio Bekic Department of Orthopedics and Traumatology, County Hospital Dubrovnik, Dubrovnik, Croatia
  • Michele Mikolaucic Department of Orthopedics and Traumatology, County Hospital Dubrovnik, Dubrovnik, Croatia
  • Vilma Kosovic Department of Radiology, County Hospital Dubrovnik, Dubrovnik, Croatia
  • Marko Golubovic
  • Vide Bilic Clinic of Traumatology, Clinical Hospital Center „Sestre milosrdnice“, Zagreb, Croatia
  • Milos Lalovac Clinic for Internal medicine, Clinical Hospital Merkur, Zagreb, Croatia



Primary non-Hodgkin's lymphoma of bone, Pathological fracture, Chemotherapy


Primary non-Hodgkin's lymphoma of the bone (PLB) is a rare entity. Patients generally present with localized bone pain, soft-tissue swelling or palpable mass. Pathological fracture of the proximal femur and humerus secondary to soft-tissue tumors is well documented in the literature. Lymphomas presenting primarily at these sites with pathological fractures are unusual. A review of the literature shows that the incidence of the skeletal manifestations from non-Hodgkin's lymphoma is less than 5%, and in all these cases, bony involvement was reported many years after the presentation of the primary cancer. Histopathologically, PLB usually represents diffuse large B-cell lymphoma. We report a 56-year-old female patient with primary non-Hodgkin's lymphoma of proximal femur with pathological fracture and management. In January 2014, a 56-year-old woman was diagnosed with stage IV B primary large-cell diffuse primary non-Hodgkin’s lymphoma. After one year of initial diagnostic procedures and chemotherapy with rituximab together with cyclophosphamide, vincristine, procarbazine, and prednisolone she achieved a complete response.


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How to Cite

Bekic, M., Mikolaucic, M., Kosovic, V., Golubovic, M., Bilic, V., & Lalovac, M. (2017). Primary Non-Hodgkin’s Lymphoma of the Bone: A case report. BioMedicine and Surgery, 1(2), 98–102.



Case report