Diagnosis of oral mycotic infections using a fluorescence detection device (VELscope®).
DOI:
https://doi.org/10.5281/zenodo.6371259Keywords:
oral mycosis, velscope, candidiasis, candida albicans, oral disease, oral pathology, oral medicineAbstract
BACKGROUND: Candida albicans is a commensal in the oral cavity of the 40-65% of the adult human population.
Diagnosis of oral candidiasis is usually based on clinical aspects, patients’ symptoms and risk factors.
Presence of Candida hyphae can be evaluated with stainingor with the culture methods.
VELscope® reveals natural tissues fluorescence produced by fluorophores of the oral mucosa is used for the screening of oral alterations.
AIM: The aim of this study is to determine sensitivity and specificity of VELscope® in the diagnosis of oral mycosis.
MATERIALS AND METHODS: Oral cavity of 29 patients has been inspected evaluating the mucosa loss of fluorescence with VELscope®. Positive outcomes of VELscope® was compared to the positive outcomes of the microbiological oral swab and the cytological smear on slides. The study was approved by the Padua Hospital Ethical Committee. The Siemel method was used in the statistical analysis.
RESULTS: VELscope® sensitivity was equal to 0.9167, CI95%=(0.6152- 0.9979), its specificity was equal to 0.1667, CI95%=(0.0209-0.4841).
The likelihood positive ratio (LR+) was of 1.1 CI95%=(0.811-1.493) and LR- of 0.5 CI95%=(0.052-4.807).
CONCLUSIONS: VELscope® sensitivity resulted higher than its specificity.
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